What if we could
cure fatal rare

Rare Monogenic Disease

Many rare diseases are caused by a single mutation in a gene, which leads to a build up of a misfolded, non-functional protein. These proteins go on to do serious damage to the cell and therefore cause often fatal disease. And very often they inhibit the ability of the cell to undergo autophagy which itself leads to more damage.

So if we boost autophagy we can remove the misfolded, cytotoxic protein, restore the cell’s ability to undergo autophagy, and in some cases we find that we can also restore the function of the mutated protein. This means restoring autophagy is not just helping an aspect of the disease but is truly curative.

In Samsara we are studying specific rare genetic liver diseases where we believe autophagy can be completely curative.

This could be life-changing for many patients suffering with severe diseases which are currently poorly treated.

The Lysoseeker™ Platform

A unique approach for discovering new autophagy therapeutics.

Rare Monogenic Disease

What if we could offer real hope for serious rare genetic diseases?


What if we could tackle the cause of Alzheimer’s and Parkinson’s Disease?

Our Pipeline

Samsara is leveraging its knowledge of new autophagy biology.

Autophagy, healthspan and lifespan

Autophagy, healthspan and lifespan

Our strategy in Samsara is to treat diseases where there is a high unmet need. But we also want to find out how our molecules work to affect healthspan and longevity.

Introducing Samsara

Introducing Samsara

Over the last twenty years or so, the phenomenon of autophagy has become a hot topic in the world of biology.

© 2021 Samsara Therapeutics | Legal Information | Privacy

© 2021 Samsara Therapeutics
Legal Information | Privacy