A selection of recent
publications from the
IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms (2021) Journal for Immunotherapy of Cancer
Digesting the crisis: autophagy and coronaviruses (2020) Microbial Cell
Importance of Quantifying Drug-Target Engagement in Cells (2020) ACS Med. Chem. Lett.
A discovery platform for the identification of caloric restriction mimetics with broad health-improving effects (2020) Autophagy
Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential (2019) Cell Metabolism
Biological Functions of Autophagy Genes: A Disease Perspective (2019)
Yeast as a tool to identify anti-aging compounds (2018) Oxford Journals: FEMS Yeast Research
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species (2018) Nature Communications
Therapeutic modulation of autophagy: Which disease comes first? (2019) Cell Death & Differentiation
The Hallmarks of Aging (2013) Cell
There is a desperate need for novel therapies that can prevent the progressive neurodegeneration in debilitating diseases of ageing, such as Alzheimer’s, Parkinson’s and Huntington’s Disease.
It’s a busy time for Samsara Therapeutics as we move into our new purpose-built labs and offices in the Wood Centre for Innovation in Oxford.
Our strategy in Samsara is to treat diseases where there is a high unmet need. But we also want to find out how our molecules work to affect healthspan and longevity.
Over the last twenty years or so, the phenomenon of autophagy has become a hot topic in the world of biology.