We are discovering new therapeutics for cellular rejuvenation
This is a new frontier of biology
What if we could discover new therapeutics that remove toxic proteins from your cell, boost your immune system and replenish your cell’s energy stores?
Autophagy is a process of cellular renewal which occurs in all the cells of the body. Its role is to clear unwanted proteins, organelles and even invading bodies such as viruses and bacteria, cutting them up into building blocks which can be used by the cell to make new proteins.
Autophagy occurs at a low level continuously but is boosted when we exercise or when we are hungry. And many studies have shown that boosting autophagy in model organisms significantly extends lifespan.
When we age, the ability of our cells to undergo autophagy reduces. And in many diseases, particularly ones which have a genetic basis, we see dysfunctional autophagy. In fact there is huge and compelling evidence from human genetics that many diseases are driven by autophagy dysfunction.
Samsara’s mission is to discover new mechanisms which can restore autophagy, and at the same time new drugs which use these mechanisms for the treatment of genetically defined diseases.
Samsara has been created by Apollo Health Ventures and features an experienced leadership team that pairs vast experience in pharma, biotech and the science of aging, and a highly skilled scientific team based in our new labs in Oxford.
Our scientific co-founders Professor Guido Kroemer and Professor Frank Madeo are world leaders in the fields of geroscience and cellular homeostasis.