Samsara Wheel

Discovering medicines that extend healthy lifespan, based on insights into the biochemical Hallmarks of Aging.

Geroscience

There is a new field of biomedical research emerging, known as geroscience, a discipline concerned with the biochemical drivers of aging and age-related disease -- known as the Hallmarks of Aging (a phrase coined by one of our scientific founders).

Over the last two decades, the geroscience community has identified several orthogonal methods of extending healthy lifespan in mammals, up to 30% in some cases. Despite this series of incredible scientific advances, there has never been a systematic industry effort to screen for new ‘geroprotectors’ or drugs that extend healthy lifespan.

Samsara Therapeutics is built on a screening platform that has identified new molecules that extend healthy lifespan across species. We then chemically optimize these hits and test them in animal models of disease and aging.

 
 

We begin with readouts of the Hallmarks of Aging in human cells and yeast with our BioCELL and CellHealth Platforms, followed by healthspan studies C. elegans, Drosophila, and mice. Most of the known ‘geroprotective’ small molecules, such as rapamycin and metformin, were discovered to extend lifespan using these short-lived model organisms.

Across species, the aging process is phylogenetically conserved – the Hallmarks of Aging in fruit flies and mice are shared with the hallmarks in humans. By slowing the aging process, Samsara does not rely on contrived animal models of disease, which have limited concordance with human pathology. A molecule that extends healthy lifespan in one species often extends lifespan in other species.

By targeting the fundamental biology of the aging process, we aim to develop drugs that can be applied to many different age related-diseases (“pipeline in a pill”).

Our Discovery Platforms
Samsara Therapeutics | Our Discovery Platforms

Team

Partnerships

Publications

  • The Hallmarks of Aging (2013) Cell.

    Read article
  • Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential. (2019) Cell Metabolism.

    Read article
  • Autophagy and the Integrated Stress Response. (2010) Molecular Cell.

    Read article
  • Biological Functions of Autophagy Genes: A Disease Perspective. (2019)

    Read article
  • Yeast as a tool to identify anti-aging compounds. (2018) Oxford Journals: FEMS Yeast Research.

    Read article
  • The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species. (2018). Nature Communications

    Read article
  • Therapeutic modulation of autophagy: Which disease comes first? (2019) Cell Death & Differentiation

    Read article

News

  • Endpoints News

    Tuesday, 26 February 2019

    An anti-aging startup called Samsara Therapeutics [...] has secured undisclosed seed funding from the aging-focused VC Apollo Ventures.

    Read article
  • Business Wire

    Tuesday, 26 February 2019

    Samsara Therapeutics Closes Seed Round Led by Apollo Ventures

    Read article
  • World Economic Forum

    Friday, 22 February 2019

    This plant eaten by Samurai could slow down ageing (video).

    Read article
  • Nature

    Tuesday, 19 February 2019

    The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species.

    Read article

Contact